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Literature summary for 2.3.1.23 extracted from
- Identification of hepatic lysophosphatidylcholine acyltransferase 3 as a novel target gene regulated by peroxisome proliferator-activated receptor delta (2017), J. Biol. Chem., 292, 884-897 .
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene LPCAT3, hepatic lysophosphatidylcholine acyltransferase 3 is encoded by a target gene regulated by peroxisome proliferator-activated receptor delta | Homo sapiens |
| gene LPCAT3, hepatic lysophosphatidylcholine acyltransferase 3 is encoded by a target gene regulated by peroxisome proliferator-activated receptor delta | Mus musculus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | transient liver-specific knockdown of LPCAT3 in mice affecting PPARdelta-mediated activation of several hepatic genes involving in fatty acid metabolism, phenotype, overview | Mus musculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| arachidonoyl-CoA + 1-acyl-sn-glycero-3-phosphocholine | Homo sapiens | - |
CoA + 1-acyl-2-arachidonoyl-sn-glycero-3-phosphocholine | - |
? |  |
| arachidonoyl-CoA + 1-acyl-sn-glycero-3-phosphocholine | Mus musculus | - |
CoA + 1-acyl-2-arachidonoyl-sn-glycero-3-phosphocholine | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q6P1A2 | - |
- |
| Mus musculus | Q91V01 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| Hep-G2 cell | - |
Homo sapiens | - |
| HEPA 1-6 cell | - |
Homo sapiens | - |
| hepatocyte | - |
Homo sapiens | - |
| Huh-7 cell | - |
Homo sapiens | - |
| liver | - |
Homo sapiens | - |
| liver | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| arachidonoyl-CoA + 1-acyl-sn-glycero-3-phosphocholine | - |
Homo sapiens | CoA + 1-acyl-2-arachidonoyl-sn-glycero-3-phosphocholine | - |
? | |
| arachidonoyl-CoA + 1-acyl-sn-glycero-3-phosphocholine | - |
Mus musculus | CoA + 1-acyl-2-arachidonoyl-sn-glycero-3-phosphocholine | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| LPCAT3 | - |
Homo sapiens |
| LPCAT3 | - |
Mus musculus |
| lysophosphatidylcholine acyltransferase 3 | - |
Homo sapiens |
| lysophosphatidylcholine acyltransferase 3 | - |
Mus musculus |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Mus musculus | hepatic LPCAT3 gene is transcriptionally regulated by peroxisome proliferator-activated receptor delta (PPARdelta). Activation of PPARdelta by agonist L165041 in mice increases hepatic LPCAT3 mRNA abundance and LPCAT enzymatic activity, which is associated with increased incorporations of arachidonate into liver phosphatidylcholine and phosphatidylethanolamine. Liver X receptor (LXR) is the important transcription factor controlling LPCAT3 expression in liver tissue via an LXR response element (LXRE) in the proximal promoter region of the murine Lpcat3 gene. The ligand-induced activation of LXR reduces hepatic inflammation and emdoplasmic reticulum stress in hyperlipidemic mice through a LPCAT3-mediated mechanism | up |
| Homo sapiens | hepatic LPCAT3 gene is transcriptionally regulated by peroxisome proliferator-activated receptor delta (PPARdelta). Adenovirus-mediated knockdown of PPARdelta in cultured hepatic cells and liver tissue reduced LPCAT3 mRNA levels, and exogenous overexpression of PPARdelta increases LPCAT3 mRNA expression. Activation of PPARdelta in Hep-G2, Huh-7, and Hepa 1-6 cells with its specific agonists increases LPCAT3 mRNA levels in all three hepatic cell lines. The functional PPAR-responsive element to a proximal region from -135 to -123 of the LPCAT3 promoter plays an essential role in mediating PPARdelta-induced transactivation of the LPCAT3 gene. Upregulation of human LPCAT3 promoter activity in HepG2 cells by PPARdelta agonists, e.g. L165041 and GW0742, and LXR agonist, e.g. GW3965. Specific interaction of PPARdelta with PPRE1 motif of LPCAT3 promoter is enhanced by ligand treatment | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | transient liver-specific knockdown of LPCAT3 in mice affects PPARdelta-mediated activation of several hepatic genes involving in fatty acid metabolism. Mice lacking LPCAT3 in the liver show reduced plasma triglycerides and hepatosteatosis and secrete lipid-poor VLDL lacking arachidonoyl phospholipids | Mus musculus |
| physiological function | hepatic lysophosphatidylcholine acyltransferase 3 (LPCAT3) has critical functions in triglycerides transport and endoplasmic reticulum stress response due to its unique ability to catalyze the incorporation of polyunsaturated fatty acids into phospholipids. Hepatic lysophosphatidylcholine acyltransferase 3 is encoded by a target gene regulated by peroxisome proliferator-activated receptor delta | Homo sapiens |
| physiological function | hepatic lysophosphatidylcholine acyltransferase 3 (LPCAT3) has critical functions in triglycerides transport and endoplasmic reticulum stress response due to its unique ability to catalyze the incorporation of polyunsaturated fatty acids into phospholipids. Hepatic lysophosphatidylcholine acyltransferase 3 is encoded by a target gene regulated by peroxisome proliferator-activated receptor delta | Mus musculus |
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